Chandrakantha, B Synthesis, Characterization and Pharmacological activity of some new substituted 1,2,4-Triazole, Pyrazole, 1,3,4- Oxadiazole and 1,3,4-Thiadiazole derivatives. Thesis thesis, Manipal Institute of Technology, Manipal. Over the past decade, drug resistance has become a growing problem in the treatment of infectious disease caused by bacteria, fungi and viruses. In particular, resistance of bacterial pathogens to current antibiotic has emerged as a measure health problem.
1,2,4-Triazoles: A Review of Synthetic Approaches and the Biological Activity
An acetic acid-promoted approach that enables the synthesis of 1,4,5-trisubstituted 1,2,3-triazole derivatives has been achieved. This transformation employs readily available primary amines, 1,3-dicarbonyls and tosyl azide as the starting materials via a cycloaddition reaction under metal-free conditions. The reaction provides a simple access to fully substituted 1,2,3-triazoles from commercial substrates in moderate to excellent yields.
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