Research paper on floating tablet

Gastro retentive effervescent floating tablets of famotidine were developed in an attempt to sustain the drug release as well as to prolong the presence of dosage form in the stomach or upper small intestine until drug is completely released in desired period of time from the formulation with special emphasis to the effect and concentration of different polymers on drug release and floatation. Based on the desired tablet properties for floating tablets as well as in vitro release characteristics best formulations were selected and subjected to in vivo radiographic studies in New Zealand white species rabbits. Shaiju S. Dharan, R. Narayana Charyulu, Mudit Dixit.
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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. During past few decades floating drug delivery systems FDDSs have been developed to prolong gastric retention time and obtain sufficient drug bioavailability [1]. To avoid unpredictable time to float due to variable pH of the gastric fluid in each subject and food in the stomach [2], sublimation technique is the new interesting approach to prepare non-effervescent FDDSs [3]. The objective of the present study was to develop the low-density film coated floating tablets using sublimable substances.
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Formulation and Evaluation of Effervescent Floating Tablet of Famotidine

Evaluation of effervescent floating matrix tablet formulations of salbutamol sulfate using full factorial design. The purpose of this research was to formulate and optimize an effervescent floating tablet formulation of salbutamol sulfate using full factorial design. Salbutamol sulfate has an absorption window in the stomach and in the upper part of the small intestine. Two viscosity grades of HPMC as matrix materials were used for formulating the tablets, which were prepared by wet granulation.
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