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BJOC - Synthesis of 1-indanones with a broad range of biological activity
At last count , over , compounds have been isolated and characterized from organisms. Among these , natural products are many familiar names — chlorophyll, caffeine, vitamin C, riboflavin, and erythromycin, to name just a few. How do toxins work? What is specifically responsible for the smell of roses, pine forests, or for that matter, poo? And are there any features they tend to have in common? There are molecules responsible for each of these phenomena, and learning about them gives you a greater appreciation for how organisms work at the molecular level, and how organisms evolve and co-evolve. One of the books that really turned me on to organic chemistry was the Merck Index , which is a doorstop of a tome containing 10, entries about molecules from the world around us, along with literature references and historical notes.
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Tyrosinase is a multi-copper enzyme which is widely distributed in different organisms and plays an important role in the melanogenesis and enzymatic browning. Therefore, its inhibitors can be attractive in cosmetics and medicinal industries as depigmentation agents and also in food and agriculture industries as antibrowning compounds. For this purpose, many natural, semi-synthetic and synthetic inhibitors have been developed by different screening methods to date. This review has focused on the tyrosinase inhibitors discovered from all sources and biochemically characterised in the last four decades.