The Ohio State University. Nonimmune type 1B diabetes , occurs secondary to other diseases and is much less common than autoimmune type 1A. The destruction of beta cells in Type 1A diabetes results from the interaction of both genetic and environmental factors. The destruction of insulin-producing beta cells in the pancreas starts with the formation of autoantigens. These autoantigens are ingested by antigen-presenting cells which activate T helper 1 Th1 and T helper 2 Th2 lmphocytes. Activated Th1 lymphocytes secrete interluekin-2 IL-2 and interferon.
Presentation R. Other medical problems include obesity and hypothyroidism. He has a history of heavy alcohol use but quit drinking alcohol 2 years ago. He is asymptomatic. There is no retinopathy or thyromegaly.