Cryogenic electron microscopy cryo-EM is an electron microscopy EM technique applied on samples cooled to cryogenic temperatures and embedded in an environment of vitreous water. An aqueous sample solution is applied to a grid-mesh and plunge-frozen in liquid ethane or a mixture of liquid ethane and propane. In , the Nobel Prize in Chemistry was awarded to Jacques Dubochet , Joachim Frank , and Richard Henderson "for developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution.
Susan Swapp, University of Wyoming. A typical SEM instrument, showing the electron column, sample chamber, EDS detector, electronics console, and visual display monitors. The scanning electron microscope SEM uses a focused beam of high-energy electrons to generate a variety of signals at the surface of solid specimens.
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